Publications

Neural Regeneration Laboratory

Smith, P.D., McLean , K.J., Murphy, M.A., Turnley, A.M. and Cook, M.J. (2005). Seizures, not hippocampal neuronal death, provoke neurogenesis in a mouse rapid electrical amygdala kindling model of seizures. Neuroscience in press.

Turnley, A.M. (2005). Role of SOCS2 in Growth Hormone Actions. Trends Endocrinol. Metab . 16, 53-58.

Turnley, A.M. (2005). Growth hormone and SOCS2 regulation of neuronal differentiation: possible role in mental function. Ped. Endocrinol. Rev. 2, 366-371.

Shen, P.-J., Yuan, C.-G., Ma, J., Cheng, S., Yao , M., Turnley, A.M. and Gundlach, A.L. (2005). Galanin in neuro(glio)genesis: Expression of galanin and receptors by progenitor cells in vivo and in vitro and effects of galanin on neurosphere proliferation. Neuropeptides. 39, 201-205.

Ransome, M.I. and Turnley, A.M. (2005). Analysis of cortical neuron subpopulations in mice over-expressing SOCS2. Neuroscience 132, 673-687.

Smith, P.D., McLean, K.J., Murphy, M.A., Wilson , Y., Murphy, M., Turnley, A.M. and Cook, M.J. (2005). A brightness-area-product based protocol for the quantitative assessment of antigen abundance in fluorescent immunohistochemistry. Brain Research Protocols 15, 21-29.

Wong. G.S.H., Goldshmit Y., and Turnley, A.M. (2004). IFN g but not TNF a promotes neuronal differentiation of neural stem cells. Exp. Neurol. 187, 171-177.

Goldshmit, Y., Walters, C.E., Scott, H.J., Greenhalgh, C.J. and Turnley, A.M. (2004). SOCS2 induces neurite outgrowth by regulation of EGF receptor activation. J. Biol. Chem. 279, 16349-16355.

Ransome, M.I., Goldshmit, Y., Bartlett , P.F., Waters, M.J. and Turnley, A.M. (2004). Comparative analysis of CNS populations in knockout mice with alterations in GH responsiveness. Eur. J. Neurosci. 19, 2069-2079 .

Goldshmit, Y., Greenhalgh, C.J. and Turnley, A.M. (2004). Suppressor of cytokine signaling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons. Eur. J. Neurosci. 20, 2260-2266 .

Goldshmit, Y., Galea, M.P., Wise, G., Bartlett , P.F. and Turnley, A.M. (2004). Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J. Neurosci. 24, 10064-10073.

Turnley, A.M., Faux, C.H., Rietze, R.L. Coonan, J.R., and Bartlett , P.F. (2002). Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling. Nature Neurosci. 5,1155-1162

Parkinson's and Alzheimer's Diseases Group

Culvenor, J.G., Ilaya, N.T., Ryan, M.T., Canterford, L., Hoke, D., Williamson, N.A., McLean, C.A., Masters, C.L., and Evin, G. (2004) Characterization of Presenilin Complex from Mouse and Human Brain using Blue Native Gel Electrophoresis Reveals High Expression in Embryonic Brain and Minimal Change in Complex Mobility with Presenilin Mutations. Eur. J. Biochem. 271, 375-385.

Smith, M. J., Sharples, R.A., Evin, G., McLean, C.A., Dean, B., Pavey, G., Fantino, E., Cotton, R.G.H., Imaizumi, K., Masters, C.L., Cappai, R., and Culvenor, J.G. (2004) Expression of Truncated Presenilin 2 Splice Variant in Alzheimer's Disease, Bipolar Disorder, and Schizophrenia Brain Cortex. Molec. Brain Res. 127, 128-135

Ilaya, NT., Evin, G., Masters, CL., and Culvenor, JG. (2004) Nicastrin Expression in Mouse Peripheral Tissues is not Co-ordinated with Presenilin and is High in Muscle. J. Neurochem. 91, 230-237.

Fodero, L.R., Mok, S.S., Losic, D., Martin, L.L., Aguilar, M-I., Barrow, C.J., Livett, B.G., and Small, D.S. (2004) a-7 Nicotinic acetylcholine receptors mediate an Ab 1-42-induced increase in the levels of acetylcholinesterase in primary cortical neurones. J. Neurochem. 88 , 1186-1193.

George AJ, Holsinger RMD, McLean CA, LaughtonKM, BeyreutherK, Evin G, MastersCL and LiQ-X. (2004) APP intracellular domain is increased and soluble Ab is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer’s disease. Neurobiol. Disease 16, 124-132.

White, A.R., Barnham K.J., Huang X., Volitakis I., Beyreuther K., Masters, C.L., Cherny R.A., Bush A.I. and Cappai, R. (2004) Iron inhibits neurotoxicity induced by trace copper and biological reductants. J. Biol. Inorg. Chem. 9, 269-280.

Multiple Sclerosis Group

Grigg A, Tubridy NJ, Szer J, Mitchell P, Butzkueven H, Shuttleworth P, KILPATRICK TJ Cladribine followed by autologous stem cell transplantation in progressive multiple sclerosis Internal Medical Journal 2004;34:66-9.

Coulson EJ, Reid K, Shipham K, Morley S, Kilpatrick TJ, Bartlett PF The role of neurotransmission and the chopper domain in p75 NTR death signaling Progress in Brain Research 2004;146:41-62.

Taylor I, Butzkueven H, Litewka L, Cook M, Mitchell P, Kilpatrick TJ, Tubridy N Serial MRI in multiple sclerosis: A prospective pilot study of lesion load, whole brain volume and thalamic atrophy J. Clin. Neurosci 2004;11:153-8.

Rubio JP, Bahlo M, Tubridy N, Wilkinson C, Johnson L, Butzkueven H, Marriott M, Carey J, Mraz G, Tait B, Speed TP, Foote SJ, Kilpatrick TJ. A common ancestral susceptibility haplotype in the HLA complex for multiple sclerosis and hemochromatosis. Hum Genet. 2004 May;114(6):573-80.

Petratos S , Gonzales MF, Azari MF, Marriott M, Minichiello RA, Shipham KA, Profyris C, Nicolaou A, Boyle A, Cheema SS, Kilpatrick TJ Expression of the low affinity neurotrophin receptor p75NTR on oligodendrocyte progenitors in chronic active MS lesions Glia. 2004 Oct;48(1):64-75.

Turner BJ, Murray SS, Piccenna LG, Lopes EC, Kilpatrick TJ, Cheema SS. Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice. J Neurosci Res. 2004 Oct 15;78(2):193

Kilpatrick TJ, Butzkueven H, Emery B, Marriott M, Taylor BV, Tubridy N. Neuroglial responses to CNS injury: prospects for novel therapeutics. Expert Rev Neurother. 2004 Sep;4(5):869-78.

Pitman M, Emery B, Binder M, Wang S, Butzkueven H, Kilpatrick, TJ. LIF Receptor Signalling Modulates Neural Stem Cell Renewal. Mol Cell Neurosci. 2004 Nov;27(3):255-66.

Ponsonby AL, van der Mei I, Dwyer T , Blizzard L, Taylor B , Kemp A, Simmons R, Kilpatrick TJ, Exposure to infant siblings during early life and risk of multiple sclerosis. JAMA 2005 Jan 26;293(4):463-9

Roxburgh RH, Seaman SR, Masterman T, Hensiek AE, Sawcer SJ, Vukusic S, Achiti I, Confavreux C, Coustans M, le Page E, Edan G, McDonnell GV, Hawkins S, Trojano M, Liguori M, Cocco E, Marrosu MG, Tesser F, Leone MA, Weber A, Zipp F, Miterski B, Epplen JT, Oturai A, Sorensen PS, Celius EG, Lara NT, Montalban X, Villoslada P, Silva AM, Marta M, Leite I, Dubois B, Rubio J, Butzkueven H, Kilpatrick T, Mycko MP, Selmaj KW, Rio ME, Sa M, Salemi G, Savettieri G, Hillert J, Compston DA. Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity. Neurology. 2005 Apr 12;64(7):1144-51